The flat wart is a viral skin disease. Its pathogens are like common warts. It is a skin neoplasm caused by infection of papillomavirus HPV3 and HPV5. The virus is mainly infected by direct contact. It can also have indirect infection through contaminated objects. Its performances are dispersed distribution with soft nature, smooth top, miliary size and pale brown color. It is above the surface of skin papules. There are many ways for the treatment of flat warts, but the effectiveness has not been quite sure. Cosmetic raw material suppliers declare that: In clinical trials, efficacy in the treatment of flat warts has been significantly improved by using retinoic acid cream combining with transferring factor.
The flat wart is mainly through direct contact, but also by pollutants, such as needles, brushes, towels and other indirect infection. In addition, trauma is an important factor in causing infection, it can usually be found that the flat wart along scratches distribution arranged in cords, and this is an example of the trauma caused by infection. In addition, people with low immunity easily transmitted than normal to flat warts. The flat wart is little risk, but it often occurs in the facial, seriously affecting the patient’s physical and mental health. Current clinical treatment for verruca plana, Chinese Herbs and topical Oral and topical anti-viral drugs, body warts subcutaneous local frozen laser and topical retinoids, but the effects are not very satisfied.
Retinoic acid is a metabolic intermediate of vitamin A, mainly affects bone growth and the promotion of epithelial cell proliferation, differentiation, Keratolytic metabolism. For the treatment of unusual acne, psoriasis, ichthyosis, lichen planus, hair, PRP, hair follicles, keratosis, squamous cell carcinoma and melanoma and other diseases. Patients can buy tretinoin from pharmacies and hospitals.
In recent years, with retinoic acid treatment of flat warts are more seen in the clinical reports, but also to obtain a certain effect. But still being explored clinically simple, low recurrence rate of treatment to meet clinical needs. Clinical trials, the use of 0.025% retinoic acid cream combined with transfer factor in treatment of flat warts, a course of the cure rate was 20.59%, and its effective rate is 85.29% treatment was significantly higher than simple topical 0.025 % retinoic acid cream in the control group. The combination therapy can improve the effectiveness.
Side effects of tretinoic are that it can cause dry skin mucous membranes, desquamation, nausea, vomiting and loss of appetite. It may also cause headache, dizziness and pain in muscle joint. Retinoic acid has a teratogenic effect for pregnant women. At the same time, it can cause liver damage, liver and kidney dysfunction. People should pay much attention to it.Source: